STAGES OF CHRONIC KIDNEY DISEASE

STAGES OF DIABETIC NEPHROPATHY

Learning Issue : How to calculate GFR?

Cockcroft-Gault Equation

When serum creatinine is measured in µmol/L:

Where Constant is 1.23 for men and 1.04 for women.

Thanks to Dr Ngiu for asking us to compare between CKD and diabetic nephropathy.

Cockcroft-Gault Equation

A commonly used surrogate marker for estimate of creatinine clearance is the Cockcroft-Gault formula, which in turn estimates GFR:It is named after the scientists who first published the formula, and it employs serum creatinine measurements and a patient's weight to predict the creatinine clearance. The formula, as originally published, is:

When serum creatinine is measured in µmol/L:

Where Constant is 1.23 for men and 1.04 for women.

One interesting feature of the Cockcroft and Gault equation is that it shows how dependent the estimation of CCr is based on age. The age term is (140 - age). This means that a 20-year-old person (140-20 = 120) will have twice the creatinine clearance as an 80-year old (140-80 = 60) for the same level of serum creatinine (120 is twice as great as 60). The C-G equation also shows that a woman will have a 15% lower creatinine clearance than a man at the same level of serum creatinine

Thanks to Dr Ngiu for asking us to compare between CKD and diabetic nephropathy.

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## 4 comments:

i not sure whether the staging in diabetic nephropathy you mentioned up there is the correct 1 or not. cz the one i found in cpg is the different 1 from you. but i will post the one i found also up there, please compare. thx.

I think you should get the other Cockcroft-Gault Equation, as the conversion unit used in UKMMC for serum creatinine is in mmol/L while the one shown is in mg/dL. You wouldn't wanna get a wrong calculation with the wrong SI unit..

It should be:

http://upload.wikimedia.org/math/0/a/0/0a08056e9f522de02986ea64301123ae.png

where the constant is 1.23 for Male and 1.04 for females.

YM, please edit my post and put the corrected one.. =)

Thnks for information...

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